RESEARCH INTERESTs

Professor Sintchenko leads a broad-ranging translational research program related to biosurveillance of bacterial diseases that are important to public health, with the aim of advancing laboratory-based surveillance and the prevention, control and management of these diseases. The work includes studies on biosurveillance, molecular diagnostics and epidemiology of pathogens with epidemic potential, and development and evaluation of decision analysis and decision support tools and programs.

Professor Sintchenko has made significant contributions to the field with his work published in top-ranked journals including Nature, Lancet and New England Journal of Medicine. 

"I am driven by health outcomes rather than discoveries of gene functions", he says. "Current surveillance systems can be slow, reactive and typically only detect large outbreaks of infectious diseases, often when the outbreak is already declining/tapering. Consequently, we are using the innovative approach of combining genomic-guided surveillance with syndromic surveillance and a multitude of additional clinical and epidemiological information, to increase the sensitivity, specificity and timeliness of detection and tracking of pathogens with epidemic potential, to detect outbreaks early and to enable our public health colleagues to mount an effective response. The funding provided by NSW Health and the infrastructure of Westmead Hospital and the SydneyID are invaluable for our efforts at capacity building to track disease outbreaks such as tuberculosis, pertussis and food-borne bacterial illnesses. Our aim is to develop scalable surveillance and tracking systems that are useful to epidemiologists, clinicians and pathologists".

FUNDED RESEARCH

  • GRANT
    A GIFT (Genomics for Infection Prevention and Therapy) to the Neighbourhood: Metagenomics enabled tracking, treatment and prevention of priority infections in culturally diverse communities
    Department of Health and Aged Care (Federal - administered by NHMRC)1 Jun 2025 - 31 May 2027
    People funded by this grant:
  • GRANT
    Australian Pathogen Genomics Program
    Department of Health and Aged Care (Federal - administered by NHMRC)1 Jun 2025 - 31 Dec 2029
    People funded by this grant:
    • Sintchenko V,
    • Howden B
  • GRANT
    Accelerating tuberculosis drug resistance discovery with a privacy-preserving distributed artificial intelligence model
    Office of Global and Research Engagement1 Jan 2025
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  • GRANT
    TB-ACQUIRE: Mechanisms and relevance of resistance against novel anti-TB drugs
    National Health and Medical Research Council (NHMRC)1 Jan 2025
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  • GRANT
    Design and evaluation of integrated legionellosis surveillance system for NSW
    NSW Health1 Jul 2024
    People funded by this grant:
  • GRANT
    Deployable Genomics-Guided Outbreak Response Program - Responding to Health Security threats in the Asia-Pacific region (ReSPOnd)
    Office of Global and Research Engagement1 Jan 2024
    People funded by this grant:
  • GRANT
    High-resolution multiscale modelling of pandemics: COVID-19 and beyond
    Australian Research Council (ARC)2 Aug 2022 - 31 Dec 2025
    People funded by this grant:
  • GRANT
    Metagenomic next generation sequencing for female sexual and reproductive health in Zambia
    Bill & Melinda Gates Foundation1 Jan 2022
    People funded by this grant:
  • GRANT
    Meta-GP: Delivering a Clinical Metagenomics Platform for Australia
    Department of Health and Aged Care (Federal)2 Jan 2021
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  • GRANT
    PPHAGE: Precision Public Health in Australia through Integrated Pathogen Genomics
    Department of Health and Aged Care (Federal)2 Jan 2021
    People funded by this grant:
  • GRANT
    Tracking COVID-19 using genomics
    Department of Health (Federal)1 Jun 2020 - 31 Dec 2022
    People funded by this grant:
    • Sintchenko V
  • GRANT
    Quantifying emergence and dynamics of foodborne epidemics in Australia
    Australian Research Council (ARC)15 Apr 2020 - 31 Dec 2023
    People funded by this grant:
  • GRANT
    Enhanced genomic tracking of COVID-19 importations and transmissions in NSW
    NSW Health1 Jan 2020
    People funded by this grant:
    • Sintchenko V
  • GRANT
    Real-time phylogenetics for food-borne outbreak surveillance
    Australian Research Council (ARC)1 Jan 2020 - 30 Sep 2024
    People funded by this grant:
    • Sintchenko V
  • GRANT
    India centric tuberculosis projects with the National Insitute for Research in Tuberculosis (NIRT), Manipal University and IIT Madras
    Faculty of Medicine and Health5 Jun 2018
    People funded by this grant:
    • Sintchenko V
  • GRANT
    Tuberculosis control in PNG
    University of Sydney5 Jun 2018 - 31 Dec 2018
    People funded by this grant:
  • GRANT
    Centre for Pathogen Discovery
    DVC Research1 Jan 2018
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  • GRANT
    Centre of Research Excellence in Tuberculosis Control on both sides of our border
    National Health and Medical Research Council (NHMRC)1 Jan 2018
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  • GRANT
    Centre of Research Excellence in tuberculosis elimination on both sides of the border
    National Health and Medical Research Council (NHMRC)1 Jan 2018
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  • GRANT
    Engineered Virulence Factors with Potential Applications in AMR and Biosurveillance
    Marie Bashir Institute for Infectious Diseases and Biosecurity1 Jan 2018
    People funded by this grant:
  • GRANT
    Reducing pertussis burden by optimising molecular epidemiological surveillance of epidemic Bordetella pertussis in Australia
    National Health and Medical Research Council (NHMRC)1 Jan 2018 - 31 Dec 2020
    People funded by this grant:
    • Lan R,
    • Sintchenko V
  • GRANT
    ARC Training Centre for Food Safety in the Fresh Produce Industry - IC160100025
    Australian Research Council (ARC)17 Feb 2017 - 16 Feb 2021
    People funded by this grant:
  • GRANT
    Centre for Pathogen Discovery
    DVC Research1 Jan 2017
    People funded by this grant:
  • GRANT
    Optimising temporal genomic surveillance of Salmonella infections in Australia
    National Health and Medical Research Council (NHMRC)1 Jan 2017 - 31 Dec 2019
    People funded by this grant:
    • Lan R,
    • Sintchenko V
  • GRANT
    Post-genomic surveillance for communicable disease control
    National Health and Medical Research Council (NHMRC)1 Jan 2017 - 31 Dec 2020
    People funded by this grant:
    • Sintchenko V