ProfessorVitali Sintchenko
Professor
Faculty of Medicine and Health
RESEARCH INTERESTs
Professor Sintchenko leads a broad-ranging translational research program related to biosurveillance of bacterial diseases that are important to public health, with the aim of advancing laboratory-based surveillance and the prevention, control and management of these diseases. The work includes studies on biosurveillance, molecular diagnostics and epidemiology of pathogens with epidemic potential, and development and evaluation of decision analysis and decision support tools and programs.
Professor Sintchenko has made significant contributions to the field with his work published in top-ranked journals including Nature, Lancet and New England Journal of Medicine.
"I am driven by health outcomes rather than discoveries of gene functions", he says. "Current surveillance systems can be slow, reactive and typically only detect large outbreaks of infectious diseases, often when the outbreak is already declining/tapering. Consequently, we are using the innovative approach of combining genomic-guided surveillance with syndromic surveillance and a multitude of additional clinical and epidemiological information, to increase the sensitivity, specificity and timeliness of detection and tracking of pathogens with epidemic potential, to detect outbreaks early and to enable our public health colleagues to mount an effective response. The funding provided by NSW Health and the infrastructure of Westmead Hospital and the SydneyID are invaluable for our efforts at capacity building to track disease outbreaks such as tuberculosis, pertussis and food-borne bacterial illnesses. Our aim is to develop scalable surveillance and tracking systems that are useful to epidemiologists, clinicians and pathologists".
FUNDED RESEARCH
- GRANTA GIFT (Genomics for Infection Prevention and Therapy) to the Neighbourhood: Metagenomics enabled tracking, treatment and prevention of priority infections in culturally diverse communitiesDepartment of Health and Aged Care (Federal - administered by NHMRC)1 Jun 2025 - 31 May 2027
- GRANTAustralian Pathogen Genomics ProgramDepartment of Health and Aged Care (Federal - administered by NHMRC)1 Jun 2025 - 31 Dec 2029People funded by this grant:
- Sintchenko V,
- Howden B
- GRANTDesign and evaluation of integrated legionellosis surveillance system for NSWNSW Health1 Jul 2024People funded by this grant:
- Sim E,
- Sintchenko V
- GRANTHigh-resolution multiscale modelling of pandemics: COVID-19 and beyondAustralian Research Council (ARC)2 Aug 2022 - 31 Dec 2025People funded by this grant:
- Sorrell T,
- Sintchenko V,
- Prokopenko M
- GRANTMetagenomic next generation sequencing for female sexual and reproductive health in ZambiaBill & Melinda Gates Foundation1 Jan 2022People funded by this grant:
- Sintchenko V,
- Rockett R,
- Golubchik T
- GRANTPPHAGE: Precision Public Health in Australia through Integrated Pathogen GenomicsDepartment of Health and Aged Care (Federal)2 Jan 2021People funded by this grant:
- Howden B,
- Marais B,
- Sintchenko V
- GRANTTracking COVID-19 using genomicsDepartment of Health (Federal)1 Jun 2020 - 31 Dec 2022People funded by this grant:
- Sintchenko V
- GRANTQuantifying emergence and dynamics of foodborne epidemics in AustraliaAustralian Research Council (ARC)15 Apr 2020 - 31 Dec 2023People funded by this grant:
- Kauffman S,
- Sintchenko V,
- Sorrell T,
- Malik A,
- Prokopenko M
- GRANTEnhanced genomic tracking of COVID-19 importations and transmissions in NSWNSW Health1 Jan 2020People funded by this grant:
- Sintchenko V
- GRANTReal-time phylogenetics for food-borne outbreak surveillanceAustralian Research Council (ARC)1 Jan 2020 - 30 Sep 2024People funded by this grant:
- Sintchenko V
- GRANTIndia centric tuberculosis projects with the National Insitute for Research in Tuberculosis (NIRT), Manipal University and IIT MadrasFaculty of Medicine and Health5 Jun 2018People funded by this grant:
- Sintchenko V
- GRANTTuberculosis control in PNGUniversity of Sydney5 Jun 2018 - 31 Dec 2018People funded by this grant:
- GRANTCentre of Research Excellence in Tuberculosis Control on both sides of our borderNational Health and Medical Research Council (NHMRC)1 Jan 2018People funded by this grant:
- Graham S,
- Marais B,
- Triccas J,
- Marks G,
- Alffenaar J-W
- GRANTReducing pertussis burden by optimising molecular epidemiological surveillance of epidemic Bordetella pertussis in AustraliaNational Health and Medical Research Council (NHMRC)1 Jan 2018 - 31 Dec 2020People funded by this grant:
- Lan R,
- Sintchenko V
- GRANTOptimising temporal genomic surveillance of Salmonella infections in AustraliaNational Health and Medical Research Council (NHMRC)1 Jan 2017 - 31 Dec 2019People funded by this grant:
- Lan R,
- Sintchenko V
- GRANTPost-genomic surveillance for communicable disease controlNational Health and Medical Research Council (NHMRC)1 Jan 2017 - 31 Dec 2020People funded by this grant:
- Sintchenko V