Research projects & supervision summary

A/Prof McGuire leads a diverse portfolio of projects focused on the intersection of single-cell proteomics and clinical translation. Current major research projects include the development of predictive immune signatures for checkpoint inhibitor response in solid tumours, the exploration of the calcification–inflammation axis in cardiovascular disease, and the characterisation of paediatric cancer immunoprofiling. A dedicated mentor, A/Prof McGuire has supervised over 15 postgraduate and honours students to completion or current candidature. Her supervision approach emphasises technical excellence and professional development, with her students consistently securing competitive scholarships and awards. She actively fosters interdisciplinary collaborations, integrating her mentees into global research networks through her leadership roles in ISAC and the Australasian Cytometry Society.

RESEARCH PROJECTS & ACTIVITIES

  • PROJECT
    Scholarship of Teaching and Learning (SoTL) Grant - 2026
    31 Mar 2026
    Project leaders:
    Collaborators:
    • McGuire H,
    • Johnsam R
    Scaling Interactive Oral Assessment in Large STEM Units: Frameworks, Student Partnership, and AI-Supported Preparation
  • RESEARCH-BASED DEGREE SUPERVISION
    Breaking the Bone: Osteoimmunological Crosstalk in the Tumour-Modified Bone Microenvironment
  • RESEARCH-BASED DEGREE SUPERVISION
    Development of Biomechanical Microtools for Investigating Live Cell Mechanobiology
  • RESEARCH-BASED DEGREE SUPERVISION
    Finding the Missing Biology in Atherosclerosis: Identification of Novel Cardiac Biomarkers Utilising the BioHEART Study
  • RESEARCH-BASED DEGREE SUPERVISION
    From Mechanism to Prediction: Defining the Spatial and Systemic Landscape of Antibody-Drug Conjugate Response in Breast Cancer
  • RESEARCH-BASED DEGREE SUPERVISION
    Immune reconstitution patterns in allogeneic haematopoietic stem cell transplant recipients with human cytomegalovirus reactivation
  • RESEARCH-BASED DEGREE SUPERVISION
    Interrogation of the immune cell complexity in colorectal cancer using mass cytometry
  • RESEARCH-BASED DEGREE SUPERVISION
    Investigating the nature and function of scavenger receptors in atherosclerosis and coronary artery disease
  • RESEARCH-BASED DEGREE SUPERVISION
    Investigating the role of tumour-draining lymph node immune dysregulation in resistance to immunotherapy
  • RESEARCH-BASED DEGREE SUPERVISION
    Investigation of immune regulators of immunotherapy outcomes in lung cancer.
  • RESEARCH-BASED DEGREE SUPERVISION
    Neuromorphic Imaging Cytometry
  • RESEARCH-BASED DEGREE SUPERVISION
    Optimising Ligand Design For The 89Zr/177Lu Theranostic Pair
  • RESEARCH-BASED DEGREE SUPERVISION
    Prevalence of psoriasis in Multiple Sclerosis in Australian adult population
  • RESEARCH-BASED DEGREE SUPERVISION
    The cellular heterogeneity of peripheral and central immune alterations in chronic pain states
  • RESEARCH-BASED DEGREE SUPERVISION
    Understanding mesothelin biology and function to enhance the efficacy of MSLN-targeted therapies against pancreatic cancer
  • RESEARCH-BASED DEGREE SUPERVISION
    Understanding the biology and functions of mesothelin and ZNF185 to enhance the efficacy of targeted therapies against pancreatic cancer