Associate ProfessorHelen McGuire
Associate Professor
Faculty of Medicine and Health
Orcid identifier0000-0003-2047-6543 (opens in a new tab)
- Associate ProfessorFaculty of Medicine and Health
RESEARCH INTERESTs
A/Prof McGuire's research is driven by a commitment to pushing the boundaries of technological development to address critical questions in clinically applied immunology. Her primary interest lies in the discovery of high-resolution "immune signatures" that define chronic clinical conditions, with a specific focus on cancer immunotherapy and cardiovascular disease. She is particularly interested in identifying blood-based biomarkers that can accurately predict patient response to checkpoint therapies, bridging the gap between advanced single-cell proteomics and precision medicine. Additionally, her work exports the immune foundations of atherosclerotic arterial disease and the development of innovative reagents and analytical tools for high-dimensional cytometry and imaging. Through these multi-disciplinary projects, she seeks to establish scalable diagnostic frameworks that improve early detection and personalised treatment strategies.
FUNDED RESEARCH
- GRANTDissecting the susceptibility of humans to coronary artery disease (CAD)Heart Research Australia1 Jan 2024People funded by this grant:
- Patrick E,
- Tang O,
- Gray M,
- McGuire H,
- Figtree GA
- GRANTImproving early diagnosis and treatment of CAD- above and beyond standard modifiable risk factors (SMuRFs)Office of Global Engagement1 Jan 2024People funded by this grant:
- Yang JYH,
- Figtree GA,
- Vernon S,
- McGuire H,
- Xiang M
- GRANTUSYD-Glasgow Biomedical Engineering Alliance: Revolutionising Cancer Immunotherapy with Triboelectric Nanogenerator (TENG)-Based Sensor Systems and zMovi High-throughput Cell Avidity Analyser PlatformOffice of Global and Research Engagement1 Aug 2023
- GRANTDissecting the susceptibility of humans to coronary artery disease (CAD)Heart Research Australia1 Jan 2023People funded by this grant:
- Ng H,
- Gray M,
- McGuire H,
- Figtree GA,
- Patrick E
- GRANTImmunoprofiling of high-risk paediatric cancerChildrens Cancer Institute Australia1 Jan 2023People funded by this grant:
- McGuire H
- GRANTDevelopment of a novel blood test that accurately predicts response to checkpoint therapy in cancer patientsNational Health and Medical Research Council (NHMRC)1 Jan 2022People funded by this grant:
- Vafaee F,
- Rankin NM,
- Fazekas de St Groth BD,
- McGuire H,
- Tsonis C
- GRANTEarly to Mid-Career Researcher Professional DevelopmentCharles Perkins Centre1 Jan 2022People funded by this grant:
- McGuire H
- GRANTUnravelling the calcification-inflammation axis to predict the risk of heart diseaseHeart Research Australia1 Jan 2021People funded by this grant:
- Figtree GA,
- Di Bartolo B,
- McGuire H
- GRANTCardiovascular Precision Medicine and Biomarker Development: Analysis of how underlying inflammatory status dictates susceptibility or resilience to coronary artery diseaseCardiovascular Initiative1 Apr 2018People funded by this grant:
- McGuire H
- GRANTEpigenetic targeting of T cell dysfunction "exhaustion" in patients failing treatment with immune checkpoint inhibitorsCancer Council NSW5 Feb 2018People funded by this grant:
- Hersey P,
- Gallagher S,
- Shklovskaya E,
- Carlino M,
- McGuire H
- GRANTRegulatory T cell therapy for prevention of graft versus host diseaseNational Health and Medical Research Council (NHMRC)1 Jan 2018 - 31 Dec 2020People funded by this grant:
- Fazekas de St Groth BD,
- Bolton HA,
- Hart D,
- McGuire H
- GRANTRES: Prediabetics CyTOF Project - The New Zealand Institute for Plant and Food Research Limited PFR - Helen McGuireNew Zealand Institute For Plant and Food Research Ltd1 Jan 2018People funded by this grant:
- McGuire H
- GRANTSystems analysis for defining the biological effect of advanced cell therapies in haematooncologySydney Medical School1 Jan 2018People funded by this grant:
- McGuire H
- GRANTDevelopment of a novel test to predict clinical response to checkpoint therapy in lung cancer and mesothelioma.University of Sydney - Sydney Catalyst Translational Cancer Research1 Jul 2017People funded by this grant:
- McGuire H
- GRANTSetting up for health or disease: Understanding how the 'Immune-Rheostat' is tuned in early lifeLifespan Research Network7 Jun 2017People funded by this grant:
- McGuire H
- GRANTSMS ECR Overseas Conference Support - McGuireSydney Medical School1 Jan 2017People funded by this grant:
- McGuire H
- GRANTThe Sydney 1000 Cancer Project – Stage 1 Gastrointestinal Cancers Immunophenotyping StudyDVC Research1 Jul 2015People funded by this grant:
- Fazekas de St Groth BD,
- Diakos C,
- Pavlakis N,
- Clarke S,
- Engel A
- GRANTContained reactivity in the immune systemNational Health and Medical Research Council (NHMRC)1 Jan 2014People funded by this grant:
- McGuire H
- GRANTNational Health and Medical Research Council1 Jan 2012 - 31 Dec 2016People funded by this grant:
- Mcguire H
- GRANTIdentifying Antigen-Specific T and B Cells in Seronegative Rheumatoid Arthritis Synovial Tissue: Implications for Antigen-Specific ImmunotherapyUS Department of Defence (USA)People funded by this grant:
- McGuire H
