DrGeorgios Angelis

Dr Angelis leads and contributes to a portfolio of imaging research projects that integrate methodological innovation with clinically meaningful applications. Current work includes:

• Dynamic FDG PET for immunotherapy response assessment, examining whether Patlak kinetic modelling can differentiate malignant uptake from immune-related metabolic activity.
• Heat-stress physiology with Total Body PET, quantifying FDG-derived blood flow and metabolic changes across cardiovascular, renal, splanchnic, and metabolic systems before and after heat acclimation.
• Ultra-low-dose CT protocol optimisation, assessing quantitative PET accuracy, image quality, and lesion detectability when attenuation correction is performed with ultra-low-dose vs standard CT.
• Dual-isotope PET protocols, including same-day 68Ga-DOTATATE/18F-FDG imaging and investigations of low-count image performance.
• AIF prediction from late-time PET data, using parametric AIF models jointly reconstructed with measured TACs to reduce the need for early dynamic data.
• National PET harmonisation initiatives, including the development of preclinical PET standardisation procedures inspired by EARL guidelines.