ProfessorWojciech Chrzanowski
Head of Pharmaceutical Sciences (L2 Supervisor)
Faculty of Medicine and Health
- Head of Pharmaceutical Sciences (L2 Supervisor)Faculty of Medicine and Health
Research projects & supervision summary
Project Opportunities
Title: Precision biomanufacturing of multifuctional extracelluar vesicles/biologicals.
Summary of opportunity:
We are seeking a talented, highly skilled and motivated candidate to undertake an industry-directed PhD project that aims to develop the precision biomanufacturing processes of next-generation functional biologicals for clinical applications.
Opportunity synopsis:
We have an open position for a talented, highly skilled and motivated PhD candidate to undertake an industry-directed project that will involve an end-to-end approach to developing an understanding of the microenvioronment conditions that influence the myriad of metabolic outputs derived from probiotic fermentation and establish a framework for the biocharacterisation of the complex matrix of biologicals' components.
This project aims to develop multi-omic methodologies to characterise the assembly of biologiclas. The work will seek to identify the significant components of the next-generation functional materials (NGFM) and streamline methods for characterisation, quantification, and ultimately, standardisation of the outputs for industrial application. During this project, the candidate will work at the interface between industry and academia and have access to state-of-the-art Nano-Bio-Characterisation and Biofabrication facilities at the University of Sydney and industry partner to produce and characterise new classes of biologicals utilising microbial biofactories.
The candidate will get to work closely with the industry partner and realise the potential applications of the NGFMs with a view to the development of application-specific protocols for use in the industry. The candidate should have a strong background in bioprocessing, biomedical sciences, and microbiological sciences. An Honours or Master by research qualification is preferred for the applicant due to the advanced nature of the project and the high level of understanding and laboratory skills required to excel in this project.
RESEARCH PROJECTS & ACTIVITIES
- RESEARCH-BASED DEGREE SUPERVISIONAdvancing in-vitro blood-brain barrier models using lipid-based nanoparticles as a strategy for drug delivery
- RESEARCH-BASED DEGREE SUPERVISIONBioproduction and Bioprocessing of Probiotic Extracellular Vesicle as Multifunctional Therapeutics
- RESEARCH-BASED DEGREE SUPERVISIONCell culture strategies and natural-origin polymers
- RESEARCH-BASED DEGREE SUPERVISIONDevelop a high yield bioprocessing system to produce collagen from mammalian cells
- RESEARCH-BASED DEGREE SUPERVISIONDevelopment of an extracellular vesicle-laden hydrogel dressings for chronic wound
- RESEARCH-BASED DEGREE SUPERVISIONDevelopment of cannabinoid loaded nanoparticles and advanced materials to enable new horizons for toxicity screening
- RESEARCH-BASED DEGREE SUPERVISIONDevelopment of electrospun fiber bundles from tropoelastin based composites for ligament regeneration
- RESEARCH-BASED DEGREE SUPERVISIONDevelopment of therapeutic extracellular vesicles for the treatment of acute and chronic lung diseases
- RESEARCH-BASED DEGREE SUPERVISIONEffects of Humidity and Excipients on Aerosol Performance and Electrostatic Charge of Spray-dried Powders for Inhalation
- RESEARCH-BASED DEGREE SUPERVISIONGallium nanoparticle as an antimicrobial agent to combat antibiotic resistance
- RESEARCH-BASED DEGREE SUPERVISIONIon implanted 'Trojan horse' surfaces with antimicrobial activity
- RESEARCH-BASED DEGREE SUPERVISIONLaboratory and Clinical Development of a Novel Thymosin-based Polymer Hydrogel for Trabecular and Cortical Bone Regeneration of the Jaw
- RESEARCH-BASED DEGREE SUPERVISIONModulation & Comparative Analysis of Small Hydrophilic Molecules Release Mechanisms from Hybrid ‘Liposome-Polymer Macrogel’ Systems
- RESEARCH-BASED DEGREE SUPERVISIONPrecision biomanufacturing of postbiotics: the next-generation functional materials for pharmaceutical nutraceutical food and agriculture applications.
- RESEARCH-BASED DEGREE SUPERVISIONSkin Tissue Engineering in Burns & Reconstructive Surgery: From Cells to Surgery and the Clinical Impact of Soft Tissue Engineering
- RESEARCH-BASED DEGREE SUPERVISIONThe EV-phage Biobots – unraveling natural synergies of extracellular vesicles and bacteriophage as a multifunctional therapeutic agent for infected skin wounds
- RESEARCH-BASED DEGREE SUPERVISIONThe EV-phage Biobots – unraveling therapeutic effect of extracellular vesicles-bacteriophage conjugate for skin infections and rare skin conditions
- RESEARCH-BASED DEGREE SUPERVISIONUltrasound-Propelled Nano-Enabled Drug Delivery Systems for Lung Cancer Treatment
- RESEARCH-BASED DEGREE SUPERVISIONValidation of IRBP as a retinal treatment target and screening for human photoreceptor-specific nanoparticles for CRISPRa gene therapy
- RESEARCH-BASED DEGREE SUPERVISIONVeterinary applications of Nano-enhanced High Intensity Focused Ultrasound (HIFUn+) as a platform technology for Drug Delivery