Associate ProfessorTimothy Newsome
Associate Professor
Faculty of Science
Research projects & supervision summary
Project Opportunities
Title: Viral Commandeering of Cellular Oncogenic Signalling Pathways
Summary of opportunity:
Cell-to-cell spread of caccinia virus infection induces dramatic rearrangements to cell morphology and alterations to cell behaviour. This project will study the role of host signalling pathways in eliciting these changes.
Opportunity synopsis:
This project involves techniques such as molecular biology, biochemistry, cell biology, cell culturing, viral genetics and microscopy. Outcomes of this project are insights into host-pathogen interactions and the regulation of cell behaviour.
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Project Opportunities
Title: New treatments for MPOX
Summary of opportunity:
Mpox outbreaks pose an increasing health risk at the global level. Our current arsenal of antiviral drugs is lacking and despite the availability of vaccines, the current population is largely susceptible and there are significant challenges to widespread vaccination. The aim of this project is to increase the treatment options for MPOX disease.
Project keywords: Poxviruses, Mpox, proteomics.
Program type: PhD
Research location/building: LEES Building (F22)
Opportunity synopsis:
Here we will identify novel viral and cellular targets for antiviral development and repurposing. This strategy is based on characterising the interactome of poxvirus infection.
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Project Opportunities
Title: Signalling by SARS-CoV-2 Spike protein
Summary of opportunity:
The Spike protein of SARS-CoV-2, the causative agent of COVID-19, mediates virus entry and additionally elicits profound phenotypic changes to host cells. This project will define the molecular pathway by which Spike usurps cellular signalling pathways and determine the role in disease.
Project keywords: SARS-CoV-2, COVID-19, Spike, TGF-beta, immune evasion.
Program type: PhD
Research location/building: LEES Building (F22)
Opportunity synopsis:
The SARS-CoV-2 Spike protein leads to the induction of TGF-beta and immune suppression. This may play a role in disease. This project will define the molecular events using a range of cell-based assays using purified Spike and pseudotyped virus.
RESEARCH PROJECTS & ACTIVITIES
- RESEARCH-BASED DEGREE SUPERVISIONCold atmospheric plasma interactions with biofilm cells and the extracellular matrix
- RESEARCH-BASED DEGREE SUPERVISIONExamining the Host-Mpox Interface through Proteomics
- RESEARCH-BASED DEGREE SUPERVISIONMechanisms of viral manipulation of integrins and the TGF-β signalling pathway
- RESEARCH-BASED DEGREE SUPERVISIONPeptide Targeting of Integrin Engagement: A RaPID Approach to SARS-CoV-2
- RESEARCH-BASED DEGREE SUPERVISIONPoxvirus manipulation of the TGF-B signaling pathway
- RESEARCH-BASED DEGREE SUPERVISIONQuantifying Viral Infection at the Level of Single Cells
- RESEARCH-BASED DEGREE SUPERVISIONSynthetic biology approaches to hydrocarbon biosensors
- RESEARCH-BASED DEGREE SUPERVISIONVirus-host interactions of herpes simplex virus type-1 envelope glycoprotein E