DrMichael Gotsbacher

I'm accepting PhD students for below projects:

• A PROTAC development platform for TDP-43 as target in neurodegenerative disease. This project focuses on the high-throughput synthesis of PROTACs targeting TDP-43, as well as compound screening to identify novel ligands for different regions (e.g., N- or C-terminus) of TDP-43. The ideal candidate brings synthetic organic chemsitry training and advanced understanding of mass spectrometry. The work will be conducted in Molecular Bioscience Building and Sydney MAss Spectrometry at Charles Perkins Centre.

• Mass Spectrometry Imaging of potential neuroprotective drug leads in the brain from Parkinson's disease and Amyotrophic Lateral Sclerosis mouse models. This project will entail a strong bioanalytical focus on metabolomics/proteomic analysis of mouse brain tissues, by using latest generation mass spectrometry housed in Sydney Mass Spectrometry. The work will be conducted in collaboration with the Brain and Mind Centre, Life Animal Services and SydneyMS at Charles Perkins Centre.

• PET-compatible bacteriophages for biodistribution studies: clinically relevant phages will be labelled with dual-function tags (fluorophore for FACS sorting, chelator for radiometal), administered in infection mouse model, and PET studies will give insight into phage biodistribution. The work is conducted in collaboation with School of Veterinary Sciences, Westmead Medical Research Institute and Charles Perkins Centre.