DrMichael Gotsbacher

We are recruiting PhD students!

My lab has two research areas of interest. First, we are investigating if protein degradation is a viable approach to remove cytotoxic protein aggregates commonly found in neurodgenerative disorders. Our target protein of interest is TDP-43, which upon translocation from the nucleaus to the cytosol and aggregation, possibly causes, but certainly drives pathologies of motor neuron disease (MND), esp. Amyotrophic Lateral Sclerosis (ALS), as well as frontotermporal lobar degeneration. Sceond, our lab is interested in method development of frontier mass spectrometry (MS) analysis of small molecules (both targeted and discovery metabolomics) and proteins (via intact and native MS (of protein-ligand complexs) for ligand discovery and validation.