Mark Douglas | Research projects & activities

Professor of Infectious Diseases and Hepatic Medicine

Faculty of Medicine and Health

Professor of Infectious Diseases and Hepatic Medicine
Faculty of Medicine and Health

Current research projects include:

Developing a cure for HBV by targeting key host cellular proteins
Developing new clinical pathways to guide personalised treatment for patients with hepatitis B, using novel diagnostic techniques developed in our laboratory.
Exploring the HBV replication cycle, with a focus on secretion of HBsAg and infectious virus particles.
Developing surveillance systems to monitor for HCV antiviral resistance in against new direct acting antivirals (DAAs)
Interactions between hepatitis D virus (HDV) and HBV, including effect of HBV genotype and mutations.
Interactions between HBV or HCV and cellular metabolism, including effects on mitochondrial function and cellular lipids.

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RESEARCH-BASED DEGREE SUPERVISION
Adaptive immune features and characteristics of natural killer cells in hepatitis B infection
RESEARCH-BASED DEGREE SUPERVISION
Developing a Liquid Biopsy to Predict Outcomes of Hepatitis B Curative Interventions
RESEARCH-BASED DEGREE SUPERVISION
Development of Diagnostic Assays to Measure Hepatitis B Virus Covalently Closed Circular (ccc)DNA
RESEARCH-BASED DEGREE SUPERVISION
Effect of Hepatitis B and C Viruses on Mitochondrial Function
RESEARCH-BASED DEGREE SUPERVISION
Effect of Viral and Host Factors on Hepatitis B Virus Surface Antigen Secretion
RESEARCH-BASED DEGREE SUPERVISION
Interrogating the interconnected biological networks in liver diseases reveals the core components of a perturbed homeostatic system.
RESEARCH-BASED DEGREE SUPERVISION
Role of novel genetic variations on tissue fibrosis
RESEARCH-BASED DEGREE SUPERVISION
Targeting and Monitoring Hepatitis B Surface Antigen: The Path Towards a Chronic Hepatitis B Cure
RESEARCH-BASED DEGREE SUPERVISION
The Stability of covalently closed circular DNA during mitosis of Hepatitis B Virus infected cells
RESEARCH-BASED DEGREE SUPERVISION
Unlocking the therapeutic potential of RARRES-1: innovative treatment strategy for liver fibrosis through bioenergetics regulation

ProfessorMark Douglas