DrKristi Griffiths

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Project Opportunities

Title: Exploring the neural mechanisms of Psilocybin-assisted Psychotherapy in Anorexia Nervosa

Summary of opportunity:

The successful PhD candidate will join a collaborative research team at the InsideOut Institute to conduct a comprehensive investigation into the neural mechanisms of psilocybin-assisted psychotherapy in anorexia nervosa. This interdisciplinary project will involve the acquisition and analysis of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to explore changes in brain activity and connectivity associated with the therapeutic effects of psilocybin.

Opportunity synopsis:

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of gaining weight, and restrictive eating behaviors. While several conventional treatments exist, many individuals with anorexia nervosa do not respond adequately to these therapies. Recent studies have shown promising results in the use of psychedelic-assisted psychotherapy, particularly with psilocybin, in treating various mental health conditions. However, there is a significant knowledge gap regarding the neural mechanisms underlying the therapeutic effects of psilocybin in anorexia nervosa. This PhD opportunity aims to bridge this gap by investigating the neural correlates of psilocybin-assisted psychotherapy in individuals with anorexia nervosa using cutting-edge neuroimaging techniques.

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Project Opportunities

Title: Investigating the Neural Mechanisms of Vyvanse in Binge Eating Disorder

Summary of opportunity:

The primary aims of this research opportunity are to improve the understanding of neural circuits affected in BED, and the mechanisms associated with Vyvanse treatment in individuals with BED. The research will apply a range of connectivity methods to resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion-weighted imaging (DWI) collected before and after 8 weeks of treatment with Vyvanse. It will also involve the integration of clinical and behavioural assessments to provide a more personalised, comprehensive understanding of the neural mechanisms underlying Vyvanse's effects in BED.

Opportunity synopsis:

Binge Eating Disorder (BED) is a condition characterized by recurrent episodes of consuming large amounts of food while experiencing a loss of control. Vyvanse (Lisdexamfetamine) has shown promise as a potential treatment for BED, but the neural mechanisms underlying its therapeutic effects remain poorly understood. We are seeking a highly motivated PhD student to join our interdisciplinary team and investigate the neurobiological basis of BED and Vyvanse's effects on individuals with BED using advanced neuroimaging analytic techniques.