ProfessorGemma Figtree

L3 Supervisor & NHMRC Fellow

Faculty of Medicine and Health

RESEARCH INTERESTs

The breadth of Dr Figtree's research program spans from discovery of fundamental mechanisms and drug targets to precision medicine, clinical trials and implementation. The syndergy that this program of work has with her clinical job as an interventional cardiologist enables her to lead unique approaches to tackling cardiovascular disease. She is passionate about bringing together the future leaders of cardiovascular research from a diverse range of backgrounds to tackle the clinical problem.

Specific clinical questions that are the focus of the Figtree team's work include:

1. Mechanisms of coronary atherosclerosis in patients with no standard modifiable risk factors;

2. New blood biomarkers to detect early atherosclerosis and predict risk of heart attack;

3. Novel drug targets that tackle inflammation and oxidative stress in the heart and blood vessel;

4. Integrating advanced cardiovascular imaging, molecular markers and clinical data to predict risk;

5. Clinical trials

FUNDED RESEARCH

  • GRANT
    Detecting and treating silent CAD- innovation for equity and scale
    NSW Health1 Jul 2026
    People funded by this grant:
  • GRANT
    Developing an evidence-based clinical pathway for reducing coronary artery disease risks related to per- and polyfluoroalkyl substances (PFAS) in firefighters and communities with high exposure levels
    National Health and Medical Research Council1 Oct 2025 - 30 Sep 2028
    People funded by this grant:
    • Figtree G
  • GRANT
    Development of Heart Attack Dashboard and Community Engagement for Regional/Remote Communities
    Australian Cardiovascular Alliance Ltd1 Sep 2025
    People funded by this grant:
    • Figtree GA
  • GRANT
    PlatfOrm for DIabetic Ulcer Management (PODIUM)
    Department of Health and Aged Care (Federal)30 Jun 2025 - 29 Jun 2030
    People funded by this grant:
    • Wraight P,
    • Chen PY,
    • Thong E,
    • Keech AT,
    • Chuter V
  • GRANT
    CYP2C19 genetic testing to enhance antiplatelet drug safety and efficacy
    Medical Research Future Fund1 Jun 2025 - 31 Jan 2031
    People funded by this grant:
    • Stocker S,
    • Figtree G,
    • Freeman C,
    • Hughes S,
    • Kirkpatrick C
  • GRANT
    Using CHIP as a cost-effective tool for early detection of cardiovascular disease
    Heart Research Australia2 Sep 2024
    People funded by this grant:
    • Tang O,
    • Figtree GA
  • GRANT
    National Australian Cardiac CT Platform For Automated Cardiac CT Reporting
    Medical Research Future Fund30 Jun 2024 - 29 Jun 2029
    People funded by this grant:
    • Dwivedi G,
    • Bennamoun M,
    • Ihdayhid A,
    • Figtree G,
    • Newby D
  • GRANT
    POPSTEM: Patient-specific cardiac stem cell villages for personalised therapeutic design
    Department of Health and Aged Care (Federal - administered by NHMRC)1 Jun 2024 - 31 Dec 2029
    People funded by this grant:
    • Powell J,
    • Figtree GA
  • GRANT
    Commercialising the results of heart research with the aim of reducing the incidence of heart attacks and carrying out the detailed business plan of the Recipient.
    DVC Research1 Jan 2024
    People funded by this grant:
    • Figtree GA
  • GRANT
    CVD research program funding support
    Faculty of Medicine and Health1 Jan 2024
    People funded by this grant:
    • Figtree GA
  • GRANT
    Dissecting the susceptibility of humans to coronary artery disease (CAD)
    Heart Research Australia1 Jan 2024
    People funded by this grant:
  • GRANT
    Improving early diagnosis and treatment of CAD- above and beyond standard modifiable risk factors (SMuRFs)
    Office of Global Engagement1 Jan 2024
    People funded by this grant:
  • GRANT
    Rewarding Research 2024
    Faculty of Medicine and Health1 Jan 2024
    People funded by this grant:
    • Figtree GA
  • GRANT
    Building an Australian Cardiovascular disease Data Commons (ACDC)
    Department of Health and Aged Care (Federal)30 Jun 2023 - 30 Jun 2027
    People funded by this grant:
  • GRANT
    Advancing preclinical development of novel GPCR targeted therapeutics for heart failure
    Department of Health and Aged Care (Federal - administered by NHMRC)1 Feb 2023 - 31 Jul 2026
    People funded by this grant:
  • GRANT
    Clinical and health economics implications of routine CTCA for emergency department assessment of Aboriginal and Torres Strait Islander people at risk of acute coronary syndrome
    Department of Health and Aged Care (Federal - administered by NHMRC)1 Feb 2023 - 31 Jan 2028
    People funded by this grant:
    • Parsonage W,
    • Cullen L,
    • Mahoney R,
    • Figtree GA,
    • Greenslade J
  • GRANT
    CTCA-POC: CT Coronary Angiography Inspired Point-of-Care Technology for Enhanced Diagnosis and Monitoring of Coronary Artery Disease
    Department of Health and Aged Care (Federal - administered by NHMRC)1 Jan 2023 - 31 Dec 2025
    People funded by this grant:
  • GRANT
    Development of a New Class of Formyl Peptide Receptor 1 (FPR1) Biased Agonists for the Treatment of Myocardial Infarction
    National Health and Medical Research Council (NHMRC)1 Jan 2023
    People funded by this grant:
    • Figtree GA
  • GRANT
    Dissecting the susceptibility of humans to coronary artery disease (CAD)
    Heart Research Australia1 Jan 2023
    People funded by this grant:
  • GRANT
    Endothelial Cells: an Underappreciated Therapeutic Target in HFpEF
    National Heart Foundation of Australia1 Jan 2023
    People funded by this grant:
    • Figtree GA
  • GRANT
    Innovative solutions towards reducing heart attacks- beyond classical risk factors
    National Health and Medical Research Council (NHMRC)1 Jan 2023
    People funded by this grant:
    • Figtree GA
  • GRANT
    Novel anti-inflammatory treatment to protect against maladaptive cardiac remodelingand repair after myocardial infarction.
    Heart Research Australia1 Jan 2023
    People funded by this grant:
    • Kassiou M,
    • Barsha G,
    • Gilchrist J,
    • Figtree GA,
    • Genetzakis E
  • GRANT
    Strategies for prevention of coronary artery disease in people without traditional risk factors
    National Heart Foundation of Australia1 Jan 2023
    People funded by this grant:
    • Figtree GA,
    • Vernon S
  • GRANT
    Targeting the mitochondrial oxidative phenotype in coronary artery disease (CAD) patient-derived cells using high-throughput drug screening approach
    National Heart Foundation of Australia1 Jan 2023
    People funded by this grant:
    • Ng H,
    • Lee E,
    • Figtree GA
  • GRANT
    The NARNIA study - Novel Application of Radiotracers and Non-invasive Imaging techniques in Atherosclerosis and cardiovascular diseases.
    Heart Research Australia1 Jan 2023
    People funded by this grant: