ProfessorGemma Figtree
L3 Supervisor & NHMRC Fellow
Faculty of Medicine and Health
- L3 Supervisor & NHMRC FellowFaculty of Medicine and Health
RESEARCH INTERESTs
The breadth of Dr Figtree's research program spans from discovery of fundamental mechanisms and drug targets to precision medicine, clinical trials and implementation. The syndergy that this program of work has with her clinical job as an interventional cardiologist enables her to lead unique approaches to tackling cardiovascular disease. She is passionate about bringing together the future leaders of cardiovascular research from a diverse range of backgrounds to tackle the clinical problem.
Specific clinical questions that are the focus of the Figtree team's work include:
1. Mechanisms of coronary atherosclerosis in patients with no standard modifiable risk factors;
2. New blood biomarkers to detect early atherosclerosis and predict risk of heart attack;
3. Novel drug targets that tackle inflammation and oxidative stress in the heart and blood vessel;
4. Integrating advanced cardiovascular imaging, molecular markers and clinical data to predict risk;
5. Clinical trials
FUNDED RESEARCH
- GRANTDeveloping an evidence-based clinical pathway for reducing coronary artery disease risks related to per- and polyfluoroalkyl substances (PFAS) in firefighters and communities with high exposure levelsNational Health and Medical Research Council1 Oct 2025 - 30 Sep 2028People funded by this grant:
- Figtree G
- GRANTDevelopment of Heart Attack Dashboard and Community Engagement for Regional/Remote CommunitiesAustralian Cardiovascular Alliance Ltd1 Sep 2025People funded by this grant:
- Figtree GA
- GRANTPlatfOrm for DIabetic Ulcer Management (PODIUM)Department of Health and Aged Care (Federal)30 Jun 2025 - 29 Jun 2030People funded by this grant:
- Wraight P,
- Chen PY,
- Thong E,
- Keech AT,
- Chuter V
- GRANTCYP2C19 genetic testing to enhance antiplatelet drug safety and efficacyMedical Research Future Fund1 Jun 2025 - 31 Jan 2031People funded by this grant:
- Stocker S,
- Figtree G,
- Freeman C,
- Hughes S,
- Kirkpatrick C
- GRANTUsing CHIP as a cost-effective tool for early detection of cardiovascular diseaseHeart Research Australia2 Sep 2024People funded by this grant:
- Tang O,
- Figtree GA
- GRANTNational Australian Cardiac CT Platform For Automated Cardiac CT ReportingMedical Research Future Fund30 Jun 2024 - 29 Jun 2029People funded by this grant:
- Dwivedi G,
- Bennamoun M,
- Ihdayhid A,
- Figtree G,
- Newby D
- GRANTPOPSTEM: Patient-specific cardiac stem cell villages for personalised therapeutic designDepartment of Health and Aged Care (Federal - administered by NHMRC)1 Jun 2024 - 31 Dec 2029People funded by this grant:
- Powell J,
- Figtree GA
- GRANTCommercialising the results of heart research with the aim of reducing the incidence of heart attacks and carrying out the detailed business plan of the Recipient.DVC Research1 Jan 2024People funded by this grant:
- Figtree GA
- GRANTCVD research program funding supportFaculty of Medicine and Health1 Jan 2024People funded by this grant:
- Figtree GA
- GRANTRewarding Research 2024Faculty of Medicine and Health1 Jan 2024People funded by this grant:
- Figtree GA
- GRANTBuilding an Australian Cardiovascular disease Data Commons (ACDC)Department of Health and Aged Care (Federal)30 Jun 2023 - 30 Jun 2027People funded by this grant:
- Figtree GA,
- Keech AT
- GRANTAdvancing preclinical development of novel GPCR targeted therapeutics for heart failureDepartment of Health and Aged Care (Federal - administered by NHMRC)1 Feb 2023 - 31 Jul 2026People funded by this grant:
- Figtree GA,
- Ng H,
- Yang JYH
- GRANTClinical and health economics implications of routine CTCA for emergency department assessment of Aboriginal and Torres Strait Islander people at risk of acute coronary syndromeDepartment of Health and Aged Care (Federal - administered by NHMRC)1 Feb 2023 - 31 Jan 2028People funded by this grant:
- Parsonage W,
- Cullen L,
- Mahoney R,
- Figtree GA,
- Greenslade J
- GRANTDevelopment of a New Class of Formyl Peptide Receptor 1 (FPR1) Biased Agonists for the Treatment of Myocardial InfarctionNational Health and Medical Research Council (NHMRC)1 Jan 2023People funded by this grant:
- Figtree GA
- GRANTEndothelial Cells: an Underappreciated Therapeutic Target in HFpEFNational Heart Foundation of Australia1 Jan 2023People funded by this grant:
- Figtree GA
- GRANTInnovative solutions towards reducing heart attacks- beyond classical risk factorsNational Health and Medical Research Council (NHMRC)1 Jan 2023People funded by this grant:
- Figtree GA
- GRANTNovel anti-inflammatory treatment to protect against maladaptive cardiac remodelingand repair after myocardial infarction.Heart Research Australia1 Jan 2023People funded by this grant:
- Kassiou M,
- Barsha G,
- Gilchrist J,
- Figtree GA,
- Genetzakis E
- GRANTStrategies for prevention of coronary artery disease in people without traditional risk factorsNational Heart Foundation of Australia1 Jan 2023People funded by this grant:
- Figtree GA,
- Vernon S
- GRANTTargeting the mitochondrial oxidative phenotype in coronary artery disease (CAD) patient-derived cells using high-throughput drug screening approachNational Heart Foundation of Australia1 Jan 2023People funded by this grant:
- Ng H,
- Lee E,
- Figtree GA
- GRANTThe NARNIA study - Novel Application of Radiotracers and Non-invasive Imaging techniques in Atherosclerosis and cardiovascular diseases.Heart Research Australia1 Jan 2023People funded by this grant:
- Patel S,
- Giannotti N,
- Ugander M,
- Figtree GA,
- Angelis G