DrAnthony Cutrupi

My work has focused on generating and studying iPSC-derived neuronal models of inherited motor neuron diseases and peripheral neuropathies to better understand the pathobiology and disease mechanisms driving degeneration of motor neurons. I has a particular interest in how aging contributes to the onset and pathogenesis of late-onset neurodegenerative diseases such as amyotrophic lateral sclerosis. We are currently exploring novel strategies to induce aging in iPSC-derived neurons to generate pre-clinical models that will allow us to understand disease progression and the pathobiological changes occuring in motor neurons from presymptomatic through to end-stage disease.