RESEARCH INTERESTs

  • Phage-bacteria co-evolution and resistance dynamics — how ecological conditions (spatial structure, nutrient limitation, bacterial growth state, community complexity, abiotic stress) shape the molecular basis and trajectory of phage resistance evolution, studied through high-throughput experimental evolution and multi-omics approaches.

 

  • Bacterial adaptive strategies to phage predation — including L-form switching and transitions between resistance modes under selective pressure.

 

  • Predictive modelling of phage–bacteria interactions — development of machine learning frameworks trained on integrated phenotypic and genomic datasets to predict co-evolutionary outcomes under untested conditions.

 

  • Translational phage biology — phage pharmacokinetics during clinical therapy, therapeutic phage monitoring, and diagnostic tools for predicting phage efficacy under infection-relevant conditions.

 

  • Microbial ecology — phage-bacteria dynamics in natural and engineered ecosystems with applications in biocontrol, agriculture, and environmental management.

FUNDED RESEARCH

  • GRANT
    Staphylococcus aureus bacteraemia treated with phage therapy to improve outcomes (SABRE-Phi trial)
    National Health and Medical Research Council (NHMRC)1 Jul 2025
    People funded by this grant:
  • GRANT
    Exploring pharmacokinetics and pharmacodynamics of bacteriophages administered to patients in a single-arm, open-label trial under the Special Access Scheme
    NSW Health1 Jan 2024
    People funded by this grant: