Associate ProfessorVeysel Kayser

Project Opportunities

Title: Seasonal Flu Vaccine Development Project

Summary of opportunity:

A full-time postgraduate project is available for a suitably qualified candidate with a good honours degree in an interdisciplinary field, such as biochemistry, physical chemistry, chemical engineering, pharmaceutical science or material science, is required to undertake research studies leading to a PhD in Pharmacy. The project is highly interdisciplinary, involving the use of numerous biophysical methods in order to understand and therein gain insight to enhance the stability of seasonal flu vaccine.

Opportunity synopsis:

Applicants should have an interest in biotechnology and biophysics and experience in hands on laboratory work using biophysical methods such as light scattering and fluorescence spectroscopy, electron and optical microscopy, chromatographic methods such as SEC-HPLC, and being able to use data analysis software such as MATLAB or Igor Pro would be an added benefit. 

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Project Opportunities

Title: Developing Novel Biotherapeutics and Vaccines

Summary of opportunity:

We are looking for an enthusiastic and motivated candidate who has a background in pharmacy, chemistry, chemical engineering or an allied subject to work on the development, synthesis, stabilization, and formulation of biotherapeutics and vaccines. The project is highly interdisciplinary and available for a suitably qualified candidate with a good honours or masters degree to start immediately leading to a PhD in Pharmacy. It involves the use of numerous biophysical methods in order to understand and therein gain insight to enhance the stability of biotherapeutics and vaccines. In addition, it requires working on the development of novel approaches to study different aspects of the sample with an emphasis on degradation issues during processing steps.

Opportunity synopsis:

The research will span both fundamental, applied research and process development on a broad range of characterization, formulation and degradation issues including but not limited to study - overall stability of the protein/vaccine and structure of the protein/virus, protein aggregation, particle size, surfactant-protein/virus interactions, degradation mechanism of the biotherapeutic/vaccine by surfactants and temperature, and finding appropriate stabilizers. The candidate will have a rare opportunity to work in an academic environment, which collaborates closely with pharmaceutical companies with an aim to streamline biotherapeutics/vaccine manufacturing.

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Project Opportunities
Title: Advanced Biotherapeutics and Vaccine Development

Summary of opportunity:

This project offers PhD and postdoctoral researchers the opportunity to contribute to the development and stabilisation of next-generation biologics and vaccines for cancer, autoimmune, and infectious diseases, within a well-established research program and in collaboration with industry.

Opportunity synopsis:
We are expanding a well-established, multidisciplinary research program focused on the development and stabilisation of next-generation biologics, including monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecifics, and nanomedicine platforms, for applications in cancer, autoimmune, and infectious diseases. Some aspects of this work are conducted in collaboration with a major pharmaceutical company and are based at the Sydney Pharmacy School.

Key research areas include:

• Developing novel mAb-based drug candidates and vaccines
• Understanding and predicting protein aggregation and degradation
• Developing novel formulation strategies and analytical tools
• Applying advanced biophysical characterisation techniques such as fluorescence spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS)
• Integrating computational modelling and machine learning to support formulation design and mechanistic understanding
  
  

We invite expressions of interest from highly motivated PhD and postdoctoral researchers with backgrounds in pharmacy, chemistry, chemical engineering, biotechnology, or related fields. Successful candidates will join a dynamic and collaborative environment with strong industry links and opportunities for high-impact translational research.

----------Current Research Projects----------

• Viruses & vaccines
• Vaccine formulations
• Traditional, nanoparticle-, and protein-based vaccines
• Therapeutic monoclonal antibodies
• Biosimilar & biobetters
• Formulation of biologics
• Bispecifics
• Antibody-drug-conjugates
• Nanoparticle-antibody conjugates
• Novel protein formulations using ionic liquids and other novel additives
• Protein aggregation