ProfessorPatrick Tam

Professor Tam's research focuses on the systems-based investigation of the gene regulatory network underpinning the cellular and molecular mechanisms of body patterning during mouse development and the biology of stem cells. He pioneered the application of multiomics functional analysis, lineage tracing of barcoded cell populations, and embryo model study for analyzing the development of major body parts of mouse embryos. The embryological analysis undertaken by his team has enabled the construction of a series of fate-maps and lineage trajectories underpinned by a molecular hierachy of gene regulatory networks revealing the organization of the basic body plan of the early embryo. The in-depth knowledge of cell differentiation during early embryogenesis laid the foundation for directing the differentiation of stem cells into clinically useful cell types for therapy in regenerative medicine.