DrJacky Stoeckli

Adipose tissue lipolysis is induced during fasting via catecholamines and other fac­tors to activate lipolysis to release FFA into the circula­tion as an energy source for other tissues.These stimuli activate lipo­lysis in fat cells via elevated cAMP and acti­vation of PKA. Active PKA phosphorylates substrates like Hor­mone Sen­sitive Lipase (HSL) and the lipid droplet (LD) protein Perilipin 1 (PLIN1), releasing PLIN1 from CGI-58, leading to forma­tion of an active complex comprising Adipose Triglyc­er­ide Lipase (ATGL) and its co-activator CGI-58. This results in LD recruitment/acti­va­tion of the two lipases involved in the first two steps of lipolysis and complete hydro­lysis of TG to three molecules of FFAs and one of glycerol.

Insulin suppresses lipolysis but recently gaps have emerged in our understanding of insulin regulation of lipolysis. In view of the detrimental consequences of unsuppressed lipolysis, such as insulin resistance and fatty liver disease, it is surprising how little we know about the mechanism of this process. Jacqueline's focus is to shed light on this process and to identify novel regulators of lipolysis.

Jacqueline's research aligns with the Faculty of Science Research Strengths - Understanding Life on Earth, Molecules to Materials, Understanding Disease & Disorder in Humans, Healthy Animals, Health and Wellbeing Across the Lifespan.