ProfessorJacqueline Matthews
Deputy Head of School
Faculty of Science
RESEARCH INTERESTs
The 30,000 or so genes in your genome encode proteins that work together in a coordinated fashion to regulate every biological process in the body. Jacqui Matthews' team is interested in finding out not just how proteins achieve these important biological processes, but also whether artificial regulation of these activities through the design of specific protein inhibitors is possible. In particular, they are investigating the protein-protein and protein-DNA interactions that occur during normal cellular development and comparing them with interactions that cause diseases states such as T-cell leukemia, beta-thalassaemia and breast cancer. To do this, they are using a range of techniques including:
- molecular biology
- biophysical methods
- structural methods
Jacqui's research aligns with the Faculty of Science Research Strengths - Fundamental Laws of Nature, Molecules to Materials, Understanding Life on Earth, Understanding Disease & Disorder in Humans.
FUNDED RESEARCH
- GRANTTranscription factors find their targets by reading the epigenetic codeAustralian Research Council (ARC)1 Jan 2022 - 31 Dec 2024People funded by this grant:
- Matthews J
- GRANTCRFI-Jacqui MatthewsDVC Research1 Jan 2021People funded by this grant:
- Matthews J
- GRANTHigh Performance Single Crystal X-ray Diffraction FacilityAustralian Research Council (ARC)1 Jan 2021 - 31 Dec 2022People funded by this grant:
- Thordarson P,
- Nguyen TV,
- Beves J,
- Potts J,
- Neville S
- GRANTFungal IP7-protein interaction and invasive fungal disease: a dangerous liaison.National Health and Medical Research Council (NHMRC)1 Jan 2020People funded by this grant:
- Matthews J,
- Lev S,
- Djordjevic J
- GRANTEngineering chromatin looping factors for artificial gene regulationAustralian Research Council (ARC)1 Jan 2019 - 31 Dec 2023People funded by this grant:
- Matthews J
- GRANTMechanisms of Gene RegulationAustralian Research Council (ARC)1 Jan 2017 - 31 Dec 2020People funded by this grant:
- Matthews J
- GRANTCharacterising the Ldb1 DimerDVC Research1 Jan 2016People funded by this grant:
- Matthews J
- GRANTAssembly of transcriptional complexes in blood development and LeukaemiaDVC Research1 Jan 2015People funded by this grant:
- Matthews J
- GRANTBruker Fourier Transform Infrared Circular Dichroism AccessoryDVC Research1 Jan 2015People funded by this grant:
- Lay P,
- Lakhwani G,
- Hawkins C,
- Matthews J,
- Bilek M
- GRANTPerpetual account for Synchrotron - MatthewsAustralian Synchrotron1 Jan 2015People funded by this grant:
- Matthews J
- GRANTDeveloping inhibitors of the LM04 oncoproteinCancer Council NSW1 Jan 2014People funded by this grant:
- Matthews J,
- Kwan A
- GRANTProtein-protein interactions in the transcriptional regulation of neural developmentAustralian Research Council (ARC)1 Jan 2014 - 31 Dec 2016People funded by this grant:
- Matthews J
- GRANTUniversity of Sydney Automated Peptide Synthesis PlatformNational Health and Medical Research Council (NHMRC)1 Jan 2014People funded by this grant:
- McErlean C,
- Kassiou M,
- Clarke R,
- Matthews J,
- Lay P
- GRANTSF-61SX2/s stopped-flow fluorimeter and Service and upgrade of SX-17MV stopped-flow spectrometerNational Health and Medical Research Council (NHMRC)1 Jan 2013People funded by this grant:
- Davies M,
- Pattison D,
- Rasmussen H,
- Matthews J,
- Clarke R
- GRANTInhibiting protein-protein interactions involved in neural development and diseaseAustralian Research Council (ARC)1 Jan 2011 - 31 Dec 2013People funded by this grant:
- Matthews J,
- Cubeddu L
- GRANTLMO2-containing complexes in leukemia and blood cell developmentNational Health and Medical Research Council (NHMRC)1 Jan 2011 - 31 Dec 2014People funded by this grant:
- Guss M,
- Matthews J,
- Mackay J
- GRANTShared resource for protein discoveryAustralian Research Council (ARC)1 Jan 2011 - 2 Dec 2011People funded by this grant:
- Brown LJ,
- Stock D,
- Sunde M,
- Trewhella J,
- Mabbutt BC
- GRANTChracterising binding partners of LMO4DVC Research1 Jan 2010People funded by this grant:
- Matthews J
- GRANTApplied Biosystems 7500 Fast Real Time PCR systemNational Health and Medical Research Council (NHMRC)1 Jan 2009People funded by this grant:
- Conigrave A,
- Brand-Miller JJ,
- Gell D,
- Crossley PM,
- Crossett B
- GRANTCracking the LIM-code: Transcription factor networks in developmental biologyAustralian Research Council (ARC)1 Jan 2009People funded by this grant:
- Matthews J