ProfessorGlenda Halliday

I work on identifying and understanding the pathobiology of non-Alzheimer dementias and degenerative motor syndromes, as these syndromes are currently under-recognized, mainly affect people in their prime, can kill rapidly, and have no mechanistic therapies. I lead a large research team that uses clinical, patient-derived, and experimental models to progress knowledge on these diseases.

My research has highlighted broader pathological involvement in Parkinson's disease and especially in dementia with Lewy bodies, with recent work suggesting lysosome dysfunction and immunity are involved. In the non-Alzheimer frontotemporal dementias, the first large scale studies were initiated in my laboratory and form the basis for both pathological and clinical staging of these syndromes, with recent work targeting their biological basis. My vision is to continue to develop significant research capacity in non-Alzheimer dementias and motor syndromes, and to coalesce Australian research capacity in these areas so that significant medical advances can be made.