ProfessorArthur Conigrave
Emeritus Professor
Faculty of Science
RESEARCH INTERESTs
Our research focuses on the mechanisms that underpin nutrient sensing in the body. This includes macronutrients such as protein and their constituent amino acids, and key micronutrients such as calcium and inorganic phosphate. We study the mechanisms by which dietary nutrients are detected, and how appetite responses are prioritised and coordinated. The role of FGF21 in modulating dietary protein appetite and in selection between protein- and carbohydrate-rich food sources is one key area of concern. We also study class C G-protein coupled receptors for amino acids and divalent cations, some of which, such as the calcium-sensing receptor, whose canonical ligand binding site is occupied by L-amino acids, respond to more than one class of nutrient, depending on the composition of the local environment.
FUNDED RESEARCH
- GRANTThe Integrative Nutrition Seminar SeriesCharles Perkins Centre1 Jan 2025People funded by this grant:
- Raubenheimer D,
- Conigrave A
- GRANTTowards the rational design of calcium sensing receptor allosteric modulators for the treatment of osteoporosis and calcium handling disordersNational Health and Medical Research Council (NHMRC)1 Jan 2018People funded by this grant:
- Conigrave A,
- Leach K
- GRANTIdentifying the cellular and structural basis for skeletal fragility in Type 2 DiabetesRebecca L Cooper Medical Research Foundation1 Apr 2016People funded by this grant:
- Brennan-Speranza T,
- Conigrave A,
- Mason R
- GRANTIs FGF21 the master regulator of protein intake?Australian Research Council (ARC)4 Jan 2016People funded by this grant:
- Le Couteur D,
- Conigrave A,
- Simpson S,
- James D,
- Raubenheimer D
- GRANTEngendering biased signalling at the human calcium sensing receptor (CaSR) to correct pathophysiologyNational Health and Medical Research Council (NHMRC)1 Jan 2015People funded by this grant:
- Conigrave A,
- Mason R
- GRANTNutrient-sensing by the calcium-sensing receptor and its partnersDVC Research1 Jan 2015People funded by this grant:
- Conigrave A
- GRANTWill a novel genetic mutation save large goannas from extinctionIan Potter Foundation6 Sep 2013People funded by this grant:
- Ujvari B,
- Mun H-C,
- Conigrave A,
- Madsen T
- GRANTAllosteric modulation and biased signalling at the calcium-sensing receptorNational Health and Medical Research Council (NHMRC)1 Jan 2012People funded by this grant:
- Christopoulos A,
- Conigrave A
- GRANTA solution to the parathyroid gland secretion problemNational Health and Medical Research Council (NHMRC)1 Jan 2011People funded by this grant:
- Conigrave A,
- Ward D
- GRANTDietary nutrients, variety and the control of human energy intakeNational Health and Medical Research Council (NHMRC)1 Jan 2011People funded by this grant:
- Simpson S,
- Conigrave A
- GRANTNovel strategies for the treatment of bone disease by nutrient activators of calcium-sensing receptorsNational Health and Medical Research Council (NHMRC)1 Jan 2011People funded by this grant:
- Mason R,
- Conigrave A
- GRANTA 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron MicroscopyAustralian Research Council (ARC)1 Jan 2010People funded by this grant:
- Marc J,
- Soon L,
- Foster L,
- Braet F,
- Overall R
- GRANTApplied Biosystems 7500 Fast Real Time PCR systemNational Health and Medical Research Council (NHMRC)1 Jan 2009People funded by this grant:
- Conigrave A,
- Brand-Miller JJ,
- Gell D,
- Crossley PM,
- Crossett B
- GRANTUnderstanding the pharmacoregulation of the extracellular calcium sending receptorNational Health and Medical Research Council (NHMRC)1 Jan 2009People funded by this grant:
- Christopoulos A,
- Conigrave A,
- Christopoulos A
- GRANTMolecular mechanism and novel activators of amino acid and calcium-sensing class 3 G-protein coupled receptorsNational Health and Medical Research Council (NHMRC)1 Jan 2008People funded by this grant:
- Conigrave A,
- Hampson DR
- GRANTEnVision Xcite Multilabel ReaderNational Health and Medical Research Council (NHMRC)1 Jan 2007People funded by this grant:
- Conigrave A
- GRANTPHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer researchCancer Institute New South Wales1 Jan 2007People funded by this grant:
- Ho P,
- Conigrave A,
- Reichardt J,
- Richardson DD,
- Murphy C
- GRANTTesting the protein leverage hypothesis in humansNational Health and Medical Research Council (NHMRC)1 Jan 2007 - 31 Dec 2009People funded by this grant:
- Caterson I,
- Conigrave A,
- Simpson S,
- Brand-Miller JJ
- GRANTMolecular determinants of amino acid-dependent signalling by the calcium-sensing receptorNational Health and Medical Research Council (NHMRC)1 Jan 2006People funded by this grant:
- Conigrave A
- GRANTUniversity of Sydney - Bridging Support GrantUniversity of Sydney1 Jan 2006People funded by this grant:
- Conigrave A
- GRANTPost menopausal testing: preclinical studyInstitut De Recherches Internationales France1 Jan 2005People funded by this grant:
- Conigrave A,
- Mason R
- GRANTDevelopment of a knock0in mouse to analyse the psychological significance of aminoacid sensing by the calcium-sensing receptorDVC Research1 Jan 2004People funded by this grant:
- Conigrave A
- GRANTCalcium-sensing receptor: molecualr determination of structure-function relations.Eli Lilly Australia Pty Limited1 Jan 2002People funded by this grant:
- Conigrave A
- GRANTNutrient dependent signalling in bone via calcium sensing receptorsNational Health and Medical Research Council (NHMRC)1 Jan 2002People funded by this grant:
- Mason R,
- Conigrave A
- GRANTPerkin-Elmer: Wallac Victor2 multi-label counter and injector unit upgradeNational Health and Medical Research Council (NHMRC)1 Jan 2002People funded by this grant:
- Conigrave A