DrAlexander Sobinoff

Cancer arises from the accumulation of genomic mutations, leading to increased endogenous replication stress. In response, cancer cells activate DNA repair mechanisms to resolve this stress, generating repair intermediates. However, if these intermediates remain unresolved, they can be physically sheared during chromosome segregation, ultimately triggering mitotic catastrophe.

My current research focuses on understanding how toxic DNA repair intermediates are resolved in cancer cells, providing the framework required to develop new therapies that target these mechanisms for cancer treatment.